Born in 1941, Sadhana migrated to India from Karachi during post-partition riots. Though difficult times, she saw movies and even her dad was influenced by cinema. In fact he had named his daughter Sadhana after the famous actress Sadhana Bose. Sadhana was destined to become an actress.

Sadhana started her career with the first Sindhi film that was made in India. For her debut film 'Abana' she was paid just Re1. But she had nothing to lose and everything to gain because she got noticed by ace filmmaker S Mukerji. Sadhana was cast in 'Love In Simla' (1960) opposite newcomer Joy Mukherjee. The writing was clear on the wall. After that she kept giving good movies like 'Hum Dono' (1961), 'Mere Mehboob' (1963), 'Rajkumar' (1964) and 'Waqt' (1965). Out of the 19 films that she did, 11 were runaway success and Sadhana became the most happening actress. With soft romantic roles, she also did suspense thrillers like 'Who Kaun Thi' (1964), 'Mera Saaya' (1966) and 'Anita' (1967). Some of her co-stars were Shammi Kapoor, Rajendar Kumar, Sunil Dutt and Manoj Kumar.

She made famous the Sadhana cut and tight fitting churidaar kameezes. In 1966, she married director R K Nayyar and left the industry for marital bliss. But that haunting beauty is still fresh in everyone's mind.